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http://hdl.handle.net/11054/2342
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DC Field | Value | Language |
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dc.contributor | Barraclough, A. | en_US |
dc.contributor | England, J. | en_US |
dc.contributor | Villa, D. | en_US |
dc.contributor | Hapgood, G. | en_US |
dc.contributor | Conn, J. | en_US |
dc.contributor | Doo, N. | en_US |
dc.contributor | Gilbertson, M. | en_US |
dc.contributor | Shaw, B. | en_US |
dc.contributor | Bishton, M. | en_US |
dc.contributor | Saeed, M. | en_US |
dc.contributor | Lee, H. | en_US |
dc.contributor | Fleming, K. | en_US |
dc.contributor | Tam, C. | en_US |
dc.contributor | Douglas, G. | en_US |
dc.contributor | Cheah, C. | en_US |
dc.contributor | Ng, Z. | en_US |
dc.contributor | Rolfe, T. | en_US |
dc.contributor | Mills, A. | en_US |
dc.contributor | Hamad, N. | en_US |
dc.contributor | Cashman, H. | en_US |
dc.contributor | Gleeson, M. | en_US |
dc.contributor | Narayana, M. | en_US |
dc.contributor | Hawkes, E. | en_US |
dc.contributor | Ratnasingam, S. | en_US |
dc.contributor | Abeyakoon, C. | en_US |
dc.contributor | Chong, Geoff | en_US |
dc.contributor | Wai, S. | en_US |
dc.contributor | Ku, M. | en_US |
dc.date.accessioned | 2024-02-02T09:09:31Z | - |
dc.date.available | 2024-02-02T09:09:31Z | - |
dc.date.issued | 2023 | - |
dc.identifier.govdoc | 02332 | en_US |
dc.identifier.uri | http://hdl.handle.net/11054/2342 | - |
dc.description.abstract | Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on a histological continuum between 'lowgrade' (Grade 1, 2 and 3A FL) and diffuse large B-cell lymphoma (DLBCL) appearing to share features with each. Clinical characteristics and outcomes are poorly understood due to lack of adequate representation in prospective trials and large-scale analyses. We analyzed 157 G3BFL cases from 18 international centers, and two comparator groups; G3AFL (n=302) and DLBCL (n=548). Composite histology with DLBCL or low-grade FL occurred in approximately half of the G3BFL cases. With a median of 5 years follow-up, the overall survival and progression-free survival of G3BFL patients was better than that of DLBCL patients (P<0.001 and P<0.001, respectively); however, G3BFL patients were younger (P<0.001) with better performance status (P<0.001), less extranodal disease (P<0.001) and more frequently had normal lactate dehydrogenase (P<0.001) at baseline. The overall and progression-free survival of patients with G3BFL and G3AFL were similar (P=0.83 and P=0.80, respectively). After frontline immunochemotherapy, 24% of G3BFL relapsed; relapse rates were 63% in the DLBCL cohort and 19% in the low-grade FL cohort. Eight percent of relapses occurred beyond 5 years. In this G3BFL cohort, the revised International Prognostic Index successfully delineated risk groups, but the Follicular Lymphoma International Prognostic Index did not. We conclude that patients with immunochemotherapy-treated G3BFL have similar survival outcomes to those with G3AFL, yet a favorable baseline profile and distinctly superior prognosis compared to patients with DLBCL. | en_US |
dc.description.provenance | Submitted by Gemma Siemensma (gemmas@bhs.org.au) on 2023-11-24T02:45:50Z No. of bitstreams: 0 | en |
dc.description.provenance | Approved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2024-02-02T09:09:31Z (GMT) No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2024-02-02T09:09:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2023 | en |
dc.title | Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance. | en_US |
dc.type | Journal Article | en_US |
dc.type.specified | Article | en_US |
dc.bibliographicCitation.title | Haematologica | en_US |
dc.bibliographicCitation.volume | 108 | en_US |
dc.bibliographicCitation.issue | 9 | en_US |
dc.bibliographicCitation.stpage | 2444 | en_US |
dc.bibliographicCitation.endpage | 2453 | en_US |
dc.subject.healththesaurus | LYMPHOMA | en_US |
dc.identifier.doi | https://doi.org/10.3324/haematol.2022.281375 | en_US |
Appears in Collections: | Research Output |
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